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Nizoral mg dosage

<strong>NIZORAL</strong> TABLETS - Janssen-Cilag

NIZORAL TABLETS - Janssen-Cilag Ketoconazole is both an over-the-counter and a prescription medication. Ketoconazole exerts a fungistatic effect at plasma levels mean approx. 3.5 micrograms/mL achieved following an oral dose of 200 mg. In vitro antifungal activity.

<em>Nizoral</em> Ketoconazole Drug Information Indications, <em>Dosage</em> and.

Nizoral Ketoconazole Drug Information Indications, Dosage and. Ketoconazole is an antifungal medicine used predominantly for treating fungal infections, though it has additional properties which can help in the treatment of truncal alopecia. Learn about indications, dosage and how it is supplied for the drug Nizoral Ketoconazole.

Ketoconazole <b>Nizoral</b>® -

Ketoconazole Nizoral® - Indicated for the treatment of the following systemic fungal infections in patients who have failed or who are intolerant to other therapies: blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis 200-400 mg/day PO Do not use tablets as first-line treatment; should be used only when other effective antifungal therapy is not available or tolerated and the potential benefits are considered to outweh the potential of hepatotoxicity Avoid prescribing tablets to treat skin and nail fungal infections owing to risk of serious liver damage, adrenal gland problems, and harmful interactions with other medicines that outweh its benefit in treating these conditions, which are not approved uses of the drug (these indications were removed from labeling by the FDA in 2013) Do not use for fungal meningitis because of poor penetration into the CSF Indicated for the treatment of the following systemic fungal infections in patients who have failed or who are intolerant to other therapies: blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis Do not use tablets as first-line treatment; should be used only when other effective antifungal therapy is not available or tolerated and the potential benefits are considered to outweh the potential of hepatotoxicity Avoid prescribing tablets to treat skin and nail fungal infections owing to risk of serious liver damage, adrenal gland problems, and harmful interactions with other medicines that outweh its benefit in treating these conditions, which are not approved uses of the drug (these indications were removed from labeling by the FDA in 2013) Do not use for fungal meningitis because of poor penetration into the CSF Alopecia Headache Dizziness Hyperlipidemia Somnolence Fever Chills Bulging fontanelles Depression Gynecomastia Diarrhea Impotence Thrombocytopenia Leukopenia Hemolytic anemia Erythema multiforme Orthostatic hypotension Jaundice Dyspepsia Dysgeusia Hepatotoxicity Decreased platelet count Xeroderma Photophobia Tablets should be used only when other effective antifungal therapy is not available or tolerated and the potential benefits are considered to outweh the potential risks Hepatotoxicity has occurred with oral use, including some fatalities or requiring liver transplantation; reported with oral administration of drug; some patients had no obvious risk factors for liver disease May cause QT prolongation; coadministration with dofetilide, quinidine, pimozide, cisapride, methadone, disopyramide, dronedarone, and ranolazine is contraindicated; ketoconazole can cause elevated plasma concentrations of these drugs (by CYP3A4 inhibition) and may prolong QT intervals, sometimes resulting in life-threatening ventricular dysrhythmias such as torsades de pointes Hypersensitivity Contraindicated with dofetilide, quinidine, pimozide, cisapride, methadone, disopyramide, dronedarone, and ranolazine; can cause elevated plasma concentrations of these drugs and may prolong QT intervals, sometimes resulting in life-threatening ventricular dysrhythmias (eg, torsades de pointes) Concurrent therapy with cisapride, ergot derivatives, or triazolam (fatal cardiac arrhythmias may occur) Acute or chronic liver disease CYP3A4 metabolized HMG-Co A reductase inhibitors (eg, simvastatin, lovastatin); ketoconazole inhibits CYP3A4 and may increase risk of myopathy associated with statins Do not use tablets as first-line treatment; should be used only when other effective antifungal therapy is not available or tolerated and the potential benefits are considered to outweh the potential of hepatotoxicity (see Black Box Warnings) Avoid prescribing tablets to treat skin and nail fungal infections owing to risk of serious liver damage, adrenal gland problems, and harmful interactions with other medicines that outweh its benefit in treating these conditions, which are not approved uses of the drug (these indications were removed from labeling by the FDA in 2013) Hypersensitivity to other azoles Hepatotoxicity reported, including fatalities or liver transplantation (see Black Box Warnings) Ketoconazole decreases metabolism of midazolam PO, triazolam PO, or alprazolam and may result in prolonged hypnotic and sedative effects Coadministration of CYP3A4 metabolized HMG-Co A reductase inhibitors (eg, simvastatin, lovastatin) increases risk for myopathy (see Contraindications) Potential for gynecomastia (drug has antiandrogenic activity) Inhibits cytochrome P450-dependent synthesis of ergosterol, which in turn inhibits cell-membrane formation Cushing syndrome (off-label): Inhibition of P450 enzymes includes the first step in cortisol synthesis, cholesterol side-chain cleavage, and conversion of 11-deoxycortisol to cortisol Well distributed into inflamed joint fluid, saliva, bile, urine, breast milk, sebum, cerumen, feces, tendons, skin and soft tissue, testes; crosses blood-brain barrier poorly, with only neglible amounts reaching CSF Protein bound: 93-96% The above information is provided for general informational and educational purposes only. Ketoconazole is used in both dogs and cats to treat infections caused by fungi. Is Supplied. Ketoconazole is available as a 200 mg tablet.

Ketoconazole For Dogs Veterinary Place

Ketoconazole For Dogs Veterinary Place Serious hepatotoxicity, including cases with a fatal outcome or requiring liver transplantation has occurred with the use of oral ketoconazole. Ketoconazole is an antifungal drug sometimes given to dogs. On this page you. For some conditions the pill-form dosage may be as hh as 10 mg/lb or more.


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