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Used as monotherapy or in combination with lithium or valproate Monotherapy: 10-15 mg/day PO initially Adjunct to lithium or valproate: 10 mg/day PO initially Maintenance: 5-20 mg/day PO; not to exceed 20 mg/day 10 mg IM (short-acting); consider 5-7.5 mg for geriatric patients or if circumstances warrant; subsequent IM doses up to 10 mg may be administered 2 hours after 1st dose and 4 hours after 2nd dose; not to exceed 30 mg/day 2.5-5 mg/day PO initially IM (extended-release): 150 mg every 4 weeks in patients who are debilitated or predisposed to hypotensive episodes; not studied in patients with renal or hepatic impairment; requires deep IM administration (muscle mass in elderly may be sufficient) Orthostatic hypotension (≥20%) Weht gain, dose dependent (5-40%) Hypertrlyceridemia (≤39%) Hypercholesterolemia (≤39%) Somnolence, dose dependent (6-39%) Extrapyramidal symptoms (EPS), dose dependent (15-32%) Xerostomia (9-22%) Weakness (2-20%) Dizziness (4-18%) Accidental injury (12%) Insomnia (12%) Elevated alanine aminotransferase (ALT) level (5-12%) Constipation (9-11%) Dyspepsia (7-11%) Hyperprolactinemia (30%) Hyperglycemia (12.8%) Syncope Sudden cardiac death Hyperglycemia Diabetic coma with ketoacidosis Diabetic ketoacidosis Acute hemorrhagic pancreatitis Venous thromboembolism Immune hypersensitivity reaction Cerebrovascular disease Seizure, status epilepticus Suicidal intent Pulmonary embolism Death Neuroleptic malnant syndrome (NMS) Tardive dyskinesia Not approved for dementia-related psychosis; 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